International Journal of Health and Clinical Research

Yazarlar: Shahid Hassan, Md Ainul Haque

Konular:-

Anahtar Kelimeler:Psoriasis,Methotrexate,Azathioprine and Cyclosporine.

Özet: Objectives: This was to evaluate the clinical efficacy of methotrexate, cyclosporine and azathioprine in various age group of psoriasis patients. Methods: A total of 45 psoriasis patients were categorised into three groups (group A, group B and group C). Each group had 15 patients. Group A patients were received 10mg/week methotrexate every week on fixed day. Group B were received azathioprine 2mg/week on fixed day of week. And Group C patients were received cyclosporine 2mg/kg/day in two divided doses. PASI score was used for assessing of severity of psoriasis. Results: Most of the patients 22(48.88%) were belonged in age group of 31-45 years. Majorities of the patients of group A 5(33.33%), group B 6(40%) and group C 6(40%) had PASI score 11-20. After 12 weeks of treatment, major reduction of severity (81-100%) was seen in group A patients 10(66.67%) as compared to group B and group C patients. Conclusions: Psoriasis was more preponderance in males than female. There was no significant association seen in reduction of severity in between the different group of patients (group A, group B and group C) who were treated with methotrexate, azathioprine and cyclosporine medication respectively. But the methotrexate was more efficacious than azathioprine and cyclosporine in percentage reduction of PASI score in treatment of psoriasis patients.

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