International Journal of Health and Clinical Research

Yazarlar: Arcot Krishna Kishore, Sreeram Praveen, Sandeep Rai

Konular:-

Anahtar Kelimeler:Prevalence,Pre,Iabetes,Cardio,Etabolic,Riskfactors,First degreeType,Idiabetes mellitus.

Özet: Background: Diabetes mellitus encompasses a range of heterogeneous metabolic disorders characterized bythe inability of the body to assimilate glucose and maintain glucose homeostasis. Aims and Objectives: To find out the prevalence of Prediabetes and Cardio metabolic risk factors in first degree relatives of patients with Type2DM. Material and Methods: This cross-sectional, observational study was conducted in the Department of Medicine and Department of Biochemistry, MGM Medical College and Hospital, Navi Mumbai. A total of 100 first degree relatives of patients suffering from Type 2 DM included in the study. Results: The prevalence of Prediabetes amongst the first degree relatives of Type 2DM was found to be 26%. The prevalence of cardio metabolic risk factors observed amongst the first degree relatives of patients of Type 2 DM were: history of CVD in 12%, Over weight by BMI in 73%, Overweight by WHR in 54%, Hypertension in32%, Dyslipidemiain 47%. The prevalence of Prediabetes was found to be more in the first degree relatives of diabetes patients who were overweight (by BMI) (32.88%) than those first degree relatives with the normal weight(by BMI) (7.41%). The prevalence of Prediabetes was more in the first degree relatives of Type 2diabetes patients who were Overweight (by WHR) (37.04%) than the first degree relatives with the normal weight (byWHR) (13.04%). The mean BMI and WHR was higher in the first degree relatives of Type2 diabetes patients with Prediabetes. The mean levels of LDL and TG were higher and mean HDL was lower in the first degree relatives of Type2 diabetes patients with Prediabetes. The mean levels of FBS and PLBS was higher in the study population with Prediabetes amongst the first degree relatives of Type2 DM. Conclusion: In the present scenario of rising worldwide incidence of Diabetes, identifying the risk factors which can be amenable to prevention is important, as Diabetes increases the risk of both microvascular and macrovascular complications contributing to increased morbidity and mortality in diabetic patients. Besides increasingly prevalent sedentary lifestyle in our general population, rampant adoption of western culture including increasing intake of fast food added with the underlying genetic predisposition is alsomaking the people in general more obese and insulin resistant thus contributing to rapidly increasing incidence of diabetes in our country. It was concluded from the present study that first degree relatives of patients withType2DM patients have high prevalence of prediabetes and other cardio metabolic risk factors.

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