Asian Pacific Journal of Health Sciences

Yazarlar: Ayush Garg, Amul Mishra

Konular:-

Anahtar Kelimeler:Indapamide,Sustained release,Hypertension,In vitro dissolution,Wet granulation

Özet: The aim of the study is to formulate and to evaluate the indapamide SR tablet for the treatment of hypertension. Literature survey shows that indapamide is an anti-hypertensive and diuretic drug. The drug has been released up to 6–15 h, after taken orally. These tablets are absorbed into the systemic circulation and blood level shows the considerable peak of drug. It has been formulated as sustained release form for the betterment of therapeutic index and for maintaining constant blood levels. From the study, it has been concluded that HPMC shows the best results for the extending the release of drug. Wet granulation method is used for the preparation of these tablets. The compatibility study for optimized formulation shows satisfactory results. The evaluation of tablets was done for the hardness, friability, weight variation, thickness, drug content, in vitro buoyancy study, swelling index, in vitro dissolution studies, and stability study.

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