Records of Natural Products

Yazarlar: Mohamad Nurul Azmi Mohamad Taib, Nur Amirah Saad, Mohamad Hafizi Abu Bakar, Mohammad Tasyriq Che Omar, Ahmad Nazif Aziz, Habibah A. Wahab, Sadia Siddiq, M. Iqbal Choudhary, Marc Litaudon, Khalijah Awang

Konular:-

DOI:10.25135/rnp.227.20.11.1889

Anahtar Kelimeler:Endiandra kingiana,Cyclic polyketides,Endiandric acids,Kingianins,Α-glucosidase inhibition,Molecular docking

Özet: A phytochemical investigation of the methanolic extract of Endiandra kingiana (bark) led to the isolation of four major compounds which are kingianic acid A (1), tsangibeilin B (2), kingianin A (3) and kingianin F (4). The structures were determined by 1D- and 2D-NMR analysis in combination with HRMS experiments. The compounds were screened for their in vitro α-glucosidase inhibition activity. Among them, compounds 3-4 showed potent α-glucosidase inhibition activity with IC50 value at 11.9 ± 2.0 µM and 19.7 ± 1.5 µM, respectively. The molecular docking study found that both compounds were bound into the active site of the N-terminal of MGAM, and thus agreed with the in vitro α-glucosidase enzyme inhibition activity results.

---