Records of Natural Products

Records of Natural Products

Isolation and Characterization of Glycosidic Tyrosinase Inhibitors from Typhonium giganteum Rhizomes

Yazarlar: Penghua Shu, Huiqing Zhu, Wanrong Liu, Lingxiang Zhang, Junping Li, Mengzhu Yu, Yingying Fei, Shujing Cai, Ruihua Li, Xialan Wei, Wenhan Yi, Fugang Xiao

Cilt 15 , Sayı 5 , 2021 , Sayfalar 380-387

Konular:-

DOI:10.25135/rnp.230.21.02.1965

Anahtar Kelimeler:Typhonium giganteum,Tyrosinase inhibitor,Glycoside,Arbutin

Özet: A new hydrocinnamoyl glucoside, 1-O-(4-hydroxyhydrocinnamoyl)-β-D-glucopyranose (1), together with fifteen known glycosides, including two phenylethanoid glycosides (2–3), two cinnamoyl glycosides (4–5), six phenolic glycosides (6–11), one lignan glycoside (12) and four megastigmane glycosides (13–16) were isolated from a 95% EtOH extract of the Typhonium giganteum rhizomes. The sixteen glycosides were structurally characterized by NMR, HRESIMS, enzymatic hydrolysis and comparison with literature. Upon evaluating inhibitory activities of compounds 1–16 against mushroom tyrosinase at 25 μM, compounds 10 and 11 exhibited obvious inhibitory activities, with %inhibition values of 20.94±0.59%, 23.28±1.09%, respectively, with arbutin used as the positive control (26.21±0.58%).

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@article{2021, title={ Isolation and Characterization of Glycosidic Tyrosinase Inhibitors from Typhonium giganteum Rhizomes}, volume={15}, number={380–387}, publisher={Records of Natural Products}, author={Penghua Shu, Huiqing Zhu, Wanrong Liu, Lingxiang Zhang, Junping Li, Mengzhu Yu, Yingying Fei, Shujing Cai, Ruihua Li, Xialan Wei, Wenhan Yi, Fugang Xiao}, year={2021} }
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Penghua Shu, Huiqing Zhu, Wanrong Liu, Lingxiang Zhang, Junping Li, Mengzhu Yu, Yingying Fei, Shujing Cai, Ruihua Li, Xialan Wei, Wenhan Yi, Fugang Xiao. (2021). Isolation and Characterization of Glycosidic Tyrosinase Inhibitors from Typhonium giganteum Rhizomes (Vol. 15). Vol. 15. Records of Natural Products.
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Penghua Shu, Huiqing Zhu, Wanrong Liu, Lingxiang Zhang, Junping Li, Mengzhu Yu, Yingying Fei, Shujing Cai, Ruihua Li, Xialan Wei, Wenhan Yi, Fugang Xiao. Isolation and Characterization of Glycosidic Tyrosinase Inhibitors from Typhonium Giganteum Rhizomes. no. 380–387, Records of Natural Products, 2021.
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