Records of Natural Products

Records of Natural Products

Coumarins from Angelica dahurica and Their Antitumor Activities in Human MG-63 Osteosarcoma Cells

Yazarlar: Weizhen Chen, Guokai Wang, Ke Mei, Jianyong Zhu

Cilt 15 , Sayı 5 , 2021 , Sayfalar 356-362

Konular:-

DOI:10.25135/rnp.225.21.01.1935

Anahtar Kelimeler:Angelica dahurica,Coumarin,Apoptosis,Cytotoxicity

Özet: A new coumarin, angedahurin A (1), and seven known analogues (2−8), were isolated from the roots of Angelica dahurica. Their structures were identified by extensive NMR, IR, and HR-ESIMS spectroscopic analyses. The cytotoxicities of coumarins 1−8 against MG-63 human osteosarcoma cell lines were screened. Compound 1 showed significant cytotoxic effects against MG-63 with an IC50 value of 7.2 uM，for comparison, the positive control, 5-FU, had an IC50 value of 32.4 uM. Morphological features of apoptosis activities were evaluated in 1-induced MG-63 cells and the results confirmed MG-63 cell apoptosis in a dose-dependent manner.

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@article{2021, title={ Coumarins from Angelica dahurica and Their Antitumor Activities in Human MG-63 Osteosarcoma Cells}, volume={15}, number={356–362}, publisher={Records of Natural Products}, author={Weizhen Chen, Guokai Wang, Ke Mei, Jianyong Zhu}, year={2021} }
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Weizhen Chen, Guokai Wang, Ke Mei, Jianyong Zhu. (2021). Coumarins from Angelica dahurica and Their Antitumor Activities in Human MG-63 Osteosarcoma Cells (Vol. 15). Vol. 15. Records of Natural Products.
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Weizhen Chen, Guokai Wang, Ke Mei, Jianyong Zhu. Coumarins from Angelica Dahurica and Their Antitumor Activities in Human MG-63 Osteosarcoma Cells. no. 356–362, Records of Natural Products, 2021.
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