Records of Natural Products

Records of Natural Products

1 Eudesmane Sesquiterpenoids from Salvia plebeia

Yazarlar: Ying Lu, Yifang Chen

Cilt 15 , Sayı 6 , 2021 , Sayfalar 613-616

Konular:-

DOI:10.25135/rnp.218.20.10.1856

Anahtar Kelimeler:Eudesmane sesquiterpene,Salvia plebeia;,NO production,Inhibitory effects

Özet: A new eudesmane sesquiterpenoid (1), named sapleudesone, together with four known analogs (2-5) were isolated from the aerial parts of Salvia plebeia. The structure of compound 1 was established by NMR and HRESIMS data, and the absolute configuration of 1 was determined by comparing the experimental ECD spectrum with the calculated ECD spectra. The known compounds were identified to be salplebeone A (2), linderolide I (3), chlorantene D (4), and chlomultin B (5), respectively, by comparing the NMR data and specific rotations with reported data. All five compounds were tested for the inhibitory effects against NO production in LPS-activated RAW 264.7 macrophages. As a result, compound 2 exhibited weak inhibitory effects with an IC50 value of 42.3 ± 1.4 mM.

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@article{2021, title={1 Eudesmane Sesquiterpenoids from Salvia plebeia}, volume={15}, number={613–616}, publisher={Records of Natural Products}, author={Ying Lu, Yifang Chen}, year={2021} }
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Ying Lu, Yifang Chen. (2021). 1 Eudesmane Sesquiterpenoids from Salvia plebeia (Vol. 15). Vol. 15. Records of Natural Products.
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Ying Lu, Yifang Chen. 1 Eudesmane Sesquiterpenoids from Salvia Plebeia. no. 613–616, Records of Natural Products, 2021.
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