Records of Natural Products

Records of Natural Products

1 Microbial Transformation of (–)-α-Bisabolol Towards Bioactive Metabolites

Yazarlar: Zeynep Firat, Fatih Demirci, Betül Demirci, Hasan Kırmızıbekmez, Kemal H. C. Baser

Cilt 15 , Sayı 6 , 2021 , Sayfalar 593-601

Konular:-

DOI:10.25135/rnp.252.2004.1615

Anahtar Kelimeler:Microbial transformation,Matricaria recutita L.,Bisabolol,Antimicrobial,Antioxidant,Penicillium neocrassum

Özet: Bisabolol is one of the bioactive constituents of chamomile. It was aimed to biotransform (–)-α-bisabolol by different fungi for the production of new bioactive metabolites, which was converted to α-bisabolol oxide A and B by Thamnidium elegans. Additionally, the biotransformation by Penicillium neocrassum yielded a new metabolite, which was characterized as 2-(5-methyl-5-(6-methyl-7-oxabicyclo[4.1.0]heptan-3-yl)tetrahydrofuran-2-yl)propan-2-ol = bisafuranol. The substrate and its metabolite mixtures were tested using antioxidant DPPH• scavenging assay. Antimicrobial activity was evaluated by an in vitro microdilution assay against a panel of human pathogenic bacteria and yeasts resulting in the lowest MIC and MFC values of 150 μg/mL. (–)-α-Bisabolol was effective against Propionibacterium acnes and Staphylococcus epidermidis (75, 37.5 μg/mL, respectively). The antioxidant activity of the metabolites was found to be more effective in scavenging free radicals.

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@article{2021, title={1 Microbial Transformation of (–)-α-Bisabolol Towards Bioactive Metabolites}, volume={15}, number={593–601}, publisher={Records of Natural Products}, author={Zeynep Firat, Fatih Demirci, Betül Demirci, Hasan Kırmızıbekmez, Kemal H. C. Baser}, year={2021} }
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Zeynep Firat, Fatih Demirci, Betül Demirci, Hasan Kırmızıbekmez, Kemal H. C. Baser. (2021). 1 Microbial Transformation of (–)-α-Bisabolol Towards Bioactive Metabolites (Vol. 15). Vol. 15. Records of Natural Products.
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Zeynep Firat, Fatih Demirci, Betül Demirci, Hasan Kırmızıbekmez, Kemal H. C. Baser. 1 Microbial Transformation of (–)-α-Bisabolol Towards Bioactive Metabolites. no. 593–601, Records of Natural Products, 2021.
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