Records of Natural Products

Yazarlar: Nazli Boke Sarikahya, Ahmet C. Goren, Gaye Sumer Okkali, Süheyla Kırmızıgül

Konular:-

DOI:10.25135/rnp.241.21.02.1985

Anahtar Kelimeler:Cephalaria,Caprifoliaceae,Triterpene,Saponin,Validation,LC-HR/MS

Özet: Saponins in the Cephalaria species have a broad spectrum of biological properties and application potentials. This research aimed to develop a novel method to tentatively identify and quantify triterpenes and saponins in 22 Cephalaria species by LC-HR/MS method. In this study, we provided a broad screening of important biologically active triterpenes and saponins with high separation ability, high sensitivity and high selectivity. This is the first report to prove that Cephalaria species can be a good source of tormentic acid which has many biological activities in literature. The main triterpene compound, tormentic acid was presented at the level between 74.02 mg/kg and 75702.0 mg/kg in n-butanol extract of Cephalaria species. The source of some biologically active saponins such as davisianoside B, aristatoside C, elmalienoside A, balansoide B and scoposide B were also determined with this study, for the first time. Therefore, due to the different activities and usages of the identified compounds, these findings may find application in a number of industries such as nutraceutical, pharmaceutical, medical and cosmetic industries.

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