Records of Natural Products

Yazarlar: Hatice Kızıltaş, Zeynebe Bingöl, Ahmet C. Gören, Saleh H. Alwasel, İlhami Gülçin

Konular:-

DOI:10.25135/rnp.236.21.02.1983

Anahtar Kelimeler:Ferula orientalis,Α-glycosidase,Antioxidant activity,Phenolic compound,Acetylcholinesterase,Α-amylase

Özet: To evaluate the antioxidant activity of evaporated ethanolic extract of Ferula orientalis L. (EEFO) and lyophilized water extract of Ferula orientalis L. (WEFO) several in vitro antioxidant methods such as ABTS•+ scavenging activity, DPPH· scavenging activity, Fe3+reduction method, cupric ions (Cu2+) reduction capacity, and metal ion (Fe2+)-binding activities using ferrozine reagent were separately performed. Also, BHT, α-tocopherol and ascorbic acid were used as the standard antioxidant molecules. Moreover, some phenolic compounds that are responsible for antioxidant abilities of EEFO and WEFO were determined by LC-HRMS. EEFO and WEFO demonstrated effective antioxidant abilities when compared with the standards. EEFO demonstrated IC50 values of 1.946 µg/mL against acetylcholinesterase (AChE), 0.815 µg/mL against α-glycosidase, and 0.675 µg/mL against α-amylase.

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