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Records of Natural Products
Yazarlar: Tran Thi Minh, Nguyen Hoai Thu, Ho Khanh Toan, Tran Thuong Quang, Nguyen Thi Viet Thanh, Tran Thu Huong, Tran Van Sung
Konular:-
DOI:10.25135/rnp.252.21.03.2014
Anahtar Kelimeler:Acrostichum aureum,Pteridaceae,4-arylbutanoid sulfate,Neolignan sulfate,Cytotoxicity
Özet: The analysis of a methanol extract of mangrove plant Acrostichum aureum collected from Thai Binh coastal area led to isolation of three new compounds, 4-(3ʹ-O-sulfate-4ʹ-hydroxyphenyl)-2-butanone (1), 4-(3ʹ-O-sulfate-4ʹ-hydroxyphenyl)-2(R)-butanol (2), and dihydrodehydrodiconiferyl alcohol 9-O-sulfate (3) beside five known phenolic compounds (4-8). The structures of isolated compounds were determined by extensive analysis of their spectroscopic evidence (IR, 1D and 2D NMR, HR ESI-MS) as well as comparison with the data reported in the literature. The cytotoxic activity of these compounds was evaluated on SK-LU-1, HepG2, and MCF7 cell lines using SRB assay. The results showed that compound 4 exhibited weak cytotoxicity against three tested cell lines. The other compounds were considered as inactive in this test.