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Records of Natural Products
Yazarlar: Dong-xiang Wu, Jin-hai Yu, Xiu-qing Song, Yu-zhen Ma, Peipei Shan, Hua Zhang
Konular:-
DOI:10.25135/rnp.245.21.03.2000
Anahtar Kelimeler:Clerodendrum bungei,Abietane diterpenoid,Alpha-glucosidase
Özet: Two new rearranged abietane diterpenoids (1 and 2), together with eleven previously described analogues (3–13), were obtained from the ethanolic extract of a traditional ethnological herb, Clerodendrum bungei. The structures with absolute configurations of the new compounds were unambiguously characterized via spectroscopic methods, and that of the formerly reported crolerodendrum B (3) was corrected in the present work. Biological assessment of these isolates revealed that diterpenoids 2, 4, 6 and 12 showed significant inhibition against a-glucosidase enzyme with IC50 values in the range of 17.0–25.7 mM.