Records of Natural Products

Records of Natural Products

Neoflavonoids from the Heartwood of Dalbergia melanoxylon

Yazarlar: Zhangjun Xu, Yang Liu, Xiaowei Meng, Li Yang, Feng Shao, Ronghua Liu, Lanying Chen

Cilt 16 , Sayı 2 , 2022 , Sayfalar 200-205

Konular:-

DOI:10.25135/rnp.267.2105.2071

Anahtar Kelimeler:Dalbergia melanoxylon,Neoflavonoids,Anti-inflammatory activity,Anti-tumor activity

Özet: A new neoflavonoid, (1R,8R,9R)-pterolinuse K (1) and six known neoflavonoids (2-7) were obtained from the heartwood of Dalbergia melanoxylon. The structure of the new neoflavonoid was elucidated by extensive NMR investigation, and X-ray crystallographic analysis. Compounds 3 and 6 showed anti-inflammatory activity with IC50 values 23.14 ± 0.30 and 19.46 ± 1.02 μΜ, respectively. Compounds 2, 3, 4, 6, 7 were showed cytotoxicity on Caco-2, MDA-MB-468, MDA-MB-231, CT26 cell lines. Moreover, compounds 2, 4 exhibited the significant activity in MDA-MB-231 cell lines with IC50 values 7.54 ± 1.50 and 7.23 ± 0.40 μΜ, respectively.

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@article{2022, title={ Neoflavonoids from the Heartwood of Dalbergia melanoxylon}, volume={16}, number={200–205}, publisher={Records of Natural Products}, author={Zhangjun Xu, Yang Liu, Xiaowei Meng, Li Yang, Feng Shao, Ronghua Liu, Lanying Chen}, year={2022} }
APA
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Zhangjun Xu, Yang Liu, Xiaowei Meng, Li Yang, Feng Shao, Ronghua Liu, Lanying Chen. (2022). Neoflavonoids from the Heartwood of Dalbergia melanoxylon (Vol. 16). Vol. 16. Records of Natural Products.
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Zhangjun Xu, Yang Liu, Xiaowei Meng, Li Yang, Feng Shao, Ronghua Liu, Lanying Chen. Neoflavonoids from the Heartwood of Dalbergia Melanoxylon. no. 200–205, Records of Natural Products, 2022.
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