Records of Natural Products

Records of Natural Products

Cytotoxic Picrotoxane-type Sesquiterpenoid Lactones from Dendrobium huoshanense

Yazarlar: Xiaoxiao Chen, Jiangmiao Hu, Siyu Wu, Hongsu Zhao, Daiyin Peng, Deling Wu, Fengqing Xu

Cilt 16 , Sayı 2 , 2022 , Sayfalar 144-149

Konular:-

DOI:10.25135/rnp.260.21.04.2048

Anahtar Kelimeler:Dendrobium huoshanense,Picrotoxane-type sesquiterpene,Cytotoxicity

Özet: Bioassay-guided led to the isolation of five compounds, including a new picrotoxane-type sesquiterpene lactone, aduncin C (1), together with four known ones (2-5) from Dendrobium huoshanense. Their structures were elucidated by means of extensive spectroscopic analysis. Biological evaluation of the isolates against four human cancer cell lines indicated broad-spectrum and cytotoxic activities with IC50 values ranging from 4.08 to 26.75 μM. Among them, α-dihydropicrotoxinin (3) exhibited significant cell proliferation inhibitory activity, especially for HL-60 (IC50 5.81 μM), MCF- 7 (IC50 6.49 μM), SW-480 (IC50 6.80 μM), respectively.

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@article{2022, title={ Cytotoxic Picrotoxane-type Sesquiterpenoid Lactones from Dendrobium huoshanense}, volume={16}, number={144–149}, publisher={Records of Natural Products}, author={Xiaoxiao Chen, Jiangmiao Hu, Siyu Wu, Hongsu Zhao, Daiyin Peng, Deling Wu, Fengqing Xu}, year={2022} }
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Xiaoxiao Chen, Jiangmiao Hu, Siyu Wu, Hongsu Zhao, Daiyin Peng, Deling Wu, Fengqing Xu. (2022). Cytotoxic Picrotoxane-type Sesquiterpenoid Lactones from Dendrobium huoshanense (Vol. 16). Vol. 16. Records of Natural Products.
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Xiaoxiao Chen, Jiangmiao Hu, Siyu Wu, Hongsu Zhao, Daiyin Peng, Deling Wu, Fengqing Xu. Cytotoxic Picrotoxane-Type Sesquiterpenoid Lactones from Dendrobium Huoshanense. no. 144–149, Records of Natural Products, 2022.
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