Records of Natural Products

Yazarlar: Trinh Thi Thuy, Ba Thi Cham, Nguyen Thi Thuy Linh, Phan Thi Ngoc Bich, Sabrina Adorisio, Domenico Delfino

Konular:-

DOI:10.25135/rnp.273.2106.2117

Anahtar Kelimeler:Balanophora laxiflora hemsl. ex forbes & hemsl,Phenolic acid analogues,Antiproliferative activity,Caspase-8,Acute myeloid leukemia cell (OCI-AML),Human cancer cell lines

Özet: Four phenolic analogues isolated from Balanophora laxiflora; methylgallate (1, MG), 4-hydroxy-3-methoxycinnamaldehyde (2), 3-methoxycinnamic acid (3), and methyl caffeate (4, MC) were shown to have antiproliferative activity on acute myeloid leukemia (OCI-AML3) cells due to impaired cell cycle progression. Three of these compounds (1, 3, and 4) caused increased apoptosis and decreased proliferationin cells. Interestingly, MC (compound 4) significantly decreased the percentage of cells in S phase and G2/M phase, and significantly increased apoptosis in cells at low concentrations. Treatment with these compounds increased Fas ligand production and caspase-8/3, but not caspase-9-dependent, apoptosis. These results suggest that dosing with these compounds decreases proliferation and increases apoptosis in cell lines derived from hematological cancers.

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