Current Perspectives on Medicinal and Aromatic Plants (CUPMAP)

Yazarlar: Višnja OREŠČANİN, štefica FİN GUŠTEK

Konular:-

Anahtar Kelimeler:Bioapygin,Acidosalus,Vulvo-vaginal disorders,Vaginal pH,Herbal macerates

Özet: Objective / Purpose: The objective of the study was assessment of the clinical efficacy and safety of BioapigynÒ vaginal ointment and pessaries compared to AcidosalusÒ pessaries and vaginal probiotic in alleviating vulvo-vaginal disorders. Materials and methods: 124 females were randomly selected into four groups (each of 31 participants) and treated once a day for ten days with: A) BioapigynÒ vaginal pessaries (one pessary per day); B) 2.5 mL of BioapyginÒ vaginal ointment; C) AcidosalusÒ vaginal pessaries (one pessary per day); D) 2.5 mL of AcidosalusÒ vaginal probiotic. All the patients were subjected to gynecological examination, measurement of vaginal pH, Pap test, native and KOH test, self-assessment and clinical assessment of the symptoms at baseline and following the therapy. Results: Following the treatment with BioapiginÒ vaginal ointment, BioapigynÒ pessaries, AcidosalusÒ pessaries, AcidosalusÒ vaginal probiotic the total score of vulvo-vaginal disorders decreased for 85.2%, 88.9%, 82.7% and 78%, respectively and vaginal pH decreased between 9.1% and 14.3%. Native test showed normalization of the vaginal flora following the treatment with all four products with no significant difference among the products. Conclusion/Discussion: Both BioapigynÒ and AcidosalusÒ products were highly efficient in alleviation of vulvo-vaginal disorders. The products created unfavorable conditions for pathogenic growth through the lowering of vaginal pH value, promoting the growth of lactobacilli, creating the environment with low water activity and creating a protective layer on the damaged mucosa that creates a physical barrier to the entrance of the pathogens into the cells and enables the recovery of the vaginal mucosa.

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