International Anatolia Academic Online Journal Health Sciences

Yazarlar: Sevda Güzel, Roman PAVELA, Gamze KOKDIL

Konular:-

Anahtar Kelimeler:Antifungal activity,Aspergillus fumigatus,Agar dilution method,Vincetoxicum

Özet: Plants, plant extracts and natural compounds are important source of new drugs. Vincetoxicum species are traditionally used for the treatment of many disease in European and Chinese folk medicine. V. canescens subsp. canescens has been used for treatment of fungal infections in traditional medicine in east part of Turkey. Many biological activities including antibacterial, antifungal, antidiarrheal, antispasmodic, antileishmanial, antimalarial, cytotoxic, antifeedant and growth inhibition have been shown for several Vincetoxicum species (e.g V.rossicum, V.stocksii, V.nigrum, V.hirundinaria) in scientific reports. In this study five Vincetoxicum taxa (V. canescens subsp. canescens, V. canescens subsp. pedunculata, V. fuscatum subsp. fuscatum, V. fuscatum subsp. boissieri and V. parviflorum) were collected from their natural habitats in different parts of Turkey and thirty different polarity extracts (dichloromethane, methanol:dichloromethane (1:1), methanol) and ten total ethanol extracts were prepared from their roots and aerial parts. These extracts were evaluated for their possible antifungal activity against widespread filamentous fungus Aspergillus fumigatus by using the agar dilution method. In tested forty extracts, the highest antifungal effect was detected for dichloromethane extracts obtained from roots and aerial parts of V. parviflorum and roots of V. canescens subsp. canescens against A. fumigatus (45.86 % inhibition value). This is the first study on antifungal effect of Vincetoxicum species against A. fumigatus.

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