Harran Üniversitesi Tıp Fakültesi Dergisi

Harran Üniversitesi Tıp Fakültesi Dergisi

Effects Of Adrenomedullin On Endothelial Microparticle Release In TNF-Αlpha Stimulated In-Vitro Graft Versus Host Disease Model

Yazarlar: Fatih KURNAZ, Yasemin TORUN, Çiğdem PALA, Esma KAYA, Serdar ŞIVGIN, Leylagül KAYNAR, Bülent ESER, Fatih ŞAHİN, Ahmet ÖZTÜRK, Mustafa ÇETİN

Cilt 11 , Sayı 3 , 2014 , Sayfalar 210 - 216

Konular:-

Anahtar Kelimeler:Adrenomedullin,Graft versus host disease,Microparticle

Özet: Background: Allogeneic stem cell transplantation (SCT) is an important treatment modality used in hematological malignant disorders. Graft-versus-host disease (GVHD) is the main complication after allogeneic SCT. It is suggested that endothelial cell damage has an important role in development of GVHD. In this study we investigated the effect of adrenomedullin (AMD) in TNF-α stimulated in-vitro GVHD model since AMD has a protective effect on cells via the regulation inflammatory pathway. Materials and Methods: Umbilical cord derived endothelial cells were incubated with TNF-α for 2 hours in group1 and with TNF-α+AMD in group2 in order to make in-vitro GVHD model and see the effect of AMD. Microparticles (CD62, CD146, CD31, CD51/61) originated from endothelial cells that are the markers of injury or apoptosis were measured. Results: We found no significant difference between the microparticle levels in both groups. Although our hypothesis was to find decrement in microparticle levels in gruop2 there were increases and decreases in microparticle levels in both groups (p>0,05). Conclusion: To detect whether there is a protective effect of AMD on development of in-vitro acute GVHD model extensive studies with multiple measurements are needed. 

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@article{2014, title={Effects Of Adrenomedullin On Endothelial Microparticle Release In TNF-Αlpha Stimulated In-Vitro Graft Versus Host Disease Model}, volume={11}, number={3}, publisher={Harran Üniversitesi Tıp Fakültesi Dergisi}, author={Fatih KURNAZ,Yasemin TORUN,Çiğdem PALA,Esma KAYA,Serdar ŞIVGIN,Leylagül KAYNAR,Bülent ESER,Fatih ŞAHİN,Ahmet ÖZTÜRK,Mustafa ÇETİN}, year={2014}, pages={210–216} }
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Fatih KURNAZ,Yasemin TORUN,Çiğdem PALA,Esma KAYA,Serdar ŞIVGIN,Leylagül KAYNAR,Bülent ESER,Fatih ŞAHİN,Ahmet ÖZTÜRK,Mustafa ÇETİN. (2014). Effects Of Adrenomedullin On Endothelial Microparticle Release In TNF-Αlpha Stimulated In-Vitro Graft Versus Host Disease Model (Vol. 11, pp. 210–216). Vol. 11, pp. 210–216. Harran Üniversitesi Tıp Fakültesi Dergisi.
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Fatih KURNAZ,Yasemin TORUN,Çiğdem PALA,Esma KAYA,Serdar ŞIVGIN,Leylagül KAYNAR,Bülent ESER,Fatih ŞAHİN,Ahmet ÖZTÜRK,Mustafa ÇETİN. Effects Of Adrenomedullin On Endothelial Microparticle Release In TNF-Αlpha Stimulated In-Vitro Graft Versus Host Disease Model. no. 3, Harran Üniversitesi Tıp Fakültesi Dergisi, 2014, pp. 210–16.
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