Harran Üniversitesi Tıp Fakültesi Dergisi

Yazarlar: Suna KALENDER

Konular:-

Anahtar Kelimeler:Lead,Mercury,Oxidative Stress,Pathology,Heart

Özet: Background: Lead nitrate and mercury chloride are widespread environmental and industrial pollutant, which induces severe alterations in the body tissues of both humans and animals. In the present study, the effects of lead and mercury induced cardiotoxicity was studied in Wistar rats. Methods: Lead nitrate (LN, 45 mg/kg bw/day) and mercury chloride (MC, 0.02 mg/kg bw/day) and their combination were administered orally for four weeks. Four groups of rats were used in the study: control, LN, MC and LN plus MC groups. Malondialdehyde (MDA) level, antioxidant enzyme activities [superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx) and glutathione-S-transferase (GST)] and histopathological changes in heart tissue were evaluated. Results: Results showed that LN and MC exposure and also their combination resulted in an increase in the SOD, CAT, GPx, GST activities and also MDA levels, with respect to the control group. Light microscopic investigations revealed that mercury chloride and lead nitrate and also co-treatment of them induced histopathological changes in heart tissue. Conclusion: As a result, combination of LN plus MC was more harmful than use them alone.

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