Journal of Medicine and Palliative Care

Yazarlar: Fatoş ERSOY, Salih CESUR, Gunay TUNCER ERTEM, Kader ARSLAN, Gülşah GELİŞİGÜZEL, Cigdem ATAMAN HATİPOGLU, Sami KINIKLI

Konular:Sağlık Bilimleri ve Hizmetleri

DOI:10.47582/jompac.785044

Anahtar Kelimeler:Multidrug resistance,Klebsiella.pneumoniae,Colistin,Side effect,Neurotoxicity

Özet: Colistin is an antibiotic commonly used in the treatment of infection due to multiple drug resistant Gram negative bacilli. Colistin side effects include of nephropathy and neuropathy. Neurotoxicity due to colistin can be occur as paresthesia, dizziness, visual changes, and neuromuscular blockade with ataxia. In this article, a case of 68-year-old female patient with a diagnosis of urinary tract infection due to resistant Klebsiella pneumoniae and treatment of imipenem and colistin after the first dose of colistin and her treatment colistin was stoped upon the development of paresthesia in the lips and fingers. After discontinuation of the drug, the patient's paresthesia improved, and the treatment was continued with a combination of imipenem and trimethoprim-sulfomethoxazole. As a result, patients receiving colistin therapy should be closely monitored for symptoms of neuropathy and drug therapy should be discontinued if neurotoxicity develops.

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