Records of Natural Products

Records of Natural Products

Isolation, Characterization and Antiproliferative Activity of Secondary Metabolites from Tanacetum alyssifolium (Bornm.) Grierson

Yazarlar: Ekrem Köksal, Yakup Ulutaş, Samed Şimşek, Taha Bayraktar, Ahmet Altay, Mustafa Çatır, İbrahim Demirtaş, Ali Rıza Tüfekçi, Ali Kandemir, Cemalettin Alp, Mohammed B. Anwer Alemdar, Hüseyin Akşit

Cilt 15 , Sayı 2 , 2021 , Sayfalar 122-129

Konular:-

DOI:10.25135/rnp.201.20.07.1702

Anahtar Kelimeler:Tanacetum alyssifolium,Sesquiterpene lactones,Cytotoxicity,MCF-7 cell line

Özet: Secondary metabolites of Tanacetum alyssifolium (Bornm.) Grierson (Asteraceae) were investigated for the first time. Thirteen compounds including axillarin (1), Luteolin-7-O-β-glucoside (8) and rutin (13) as flavonoids, fraxetin (7), isofraxidin (9), isofraxidin-7-O-glucoside (11) and fraxidin (12) as coumarins, tatridin A (2), altissin (3), tamirin (4) and tanachin (5) as sesquiterpene lactones and 2,4-dihydroxy-6-methoxy acetophenone (6) and picein (10) as acetophenone derivatives were isolated from the methanol extract of the species. The structures of all isolated compounds were elucidated by 1D and 2D-NMR techniques and by comparing with the literature data. In addition, in vitro cytotoxic activity of all isolated compounds was evaluated against breast cancer MCF-7 cell line by XTT assay. Sesquiterpene lactones; tatridin A (2), tamirin (4) and tanachin (5) were found to be the most cytotoxic molecules against MCF-7 cell line.

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@article{2021, title={Isolation, Characterization and Antiproliferative Activity of Secondary Metabolites from Tanacetum alyssifolium (Bornm.) Grierson}, volume={15}, number={122–129}, publisher={Records of Natural Products}, author={Ekrem Köksal, Yakup Ulutaş, Samed Şimşek, Taha Bayraktar, Ahmet Altay, Mustafa Çatır, İbrahim Demirtaş, Ali Rıza Tüfekçi, Ali Kandemir, Cemalettin Alp, Mohammed B. Anwer Alemdar, Hüseyin Akşit}, year={2021} }
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Ekrem Köksal, Yakup Ulutaş, Samed Şimşek, Taha Bayraktar, Ahmet Altay, Mustafa Çatır, İbrahim Demirtaş, Ali Rıza Tüfekçi, Ali Kandemir, Cemalettin Alp, Mohammed B. Anwer Alemdar, Hüseyin Akşit. (2021). Isolation, Characterization and Antiproliferative Activity of Secondary Metabolites from Tanacetum alyssifolium (Bornm.) Grierson (Vol. 15). Vol. 15. Records of Natural Products.
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Ekrem Köksal, Yakup Ulutaş, Samed Şimşek, Taha Bayraktar, Ahmet Altay, Mustafa Çatır, İbrahim Demirtaş, Ali Rıza Tüfekçi, Ali Kandemir, Cemalettin Alp, Mohammed B. Anwer Alemdar, Hüseyin Akşit. Isolation, Characterization and Antiproliferative Activity of Secondary Metabolites from Tanacetum Alyssifolium (Bornm.) Grierson. no. 122–129, Records of Natural Products, 2021.
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