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Records of Natural Products
Yazarlar: Jian Zhou, Jinhua Wen, Jianhua Huang, Pengfei Chen, Xiao-Chi Ma, Rongjing Sun, Chao Wang
Konular:-
DOI:10.25135/rnp.204.20.08.1774
Anahtar Kelimeler:Euphorbia ebracteolata,Rosane diterpenoid,Ebraphenol E,Lipase,Chemotaxonomy
Özet: The phytochemical investigation has been performed for Euphorbia ebracteolata, the roots of which are usually used natural medicine in traditional Chinese medicine for the treatments of tuberculosis and bacterial infection. A diterpenoid has been obtained using silica gel and ODS column chromatography. Furthermore, on the basis of widely spectroscopic data analyses, including 1D-, 2D-NMR, HR-ESIMS and ECD, the isolated compound was determined to be a rosane type diterpenoid, which possessed a rare aromatic ring. The isolated diterpenoid as a new compound was named ebraphenol E (1). The bioactivity of isolated diterpenoid (1) has been evaluated and moderate inhibitory effect on lipase (IC50 = 12.5 μM) was observed. In combination with our previous phytochemical investigations about E. ebracteolata, the chemotaxonomic significance of diterpenoids was summarized for E. ebracteolata.