Türk Klinik Biyokimya Dergisi

Yazarlar: Hacer Koç, Özlem Çakır Madenci, Asuman Orçun, Nihal Yücel, Şeymanur Sağlam, Nurdan Papila Topal4

Konular:-

Anahtar Kelimeler:CRP,Fever,NT-proBNP,Procalcitonin,Heart failure

Özet: Objective: We aimed to investigate the NT-proBNP levels in high fever patients without heart failure, to contribute to the proper request and interpretation of the test. Methods: Patients group included 31 patients who admitted with a body temperature ≥38ºC and showed no signs of heart failure on their echocardiograms. Patients were internalized in the Infectious Diseases Clinic. The control group included 31 healthy subjects. NT-pro-BNP, Procalcitonin (Cobas e 601 Roche Diagnostics, Germany), Complete Blood Count (Beckman Coulter LH 780, USA) and CRP (Siemens BN II Nephelometer, Germany) levels were evaluated. Results: Median (2.5-97.5 % percentiles) body temperature values of the patients and controls were 38.4 (38.0 - 39.8) and 36.1 (36-36.6) C° respectively (p < 0.0001). Median (2.5-97.5 % percentiles) NTproBNP levels of the patients and control groups were; 240 (48.3- 2637) and 34.8 (5.35-86) ng/L respectively (p < 0.0001). NT-proBNP levels correlated significantly with body temperature, CRP, and PCT ( r=0.761, 0.726 and 0.727 respectively, all p’s < 0.0001). We observed recovery at 8 patients (at least 48 hours without fever), and median (2.5-97.5 % percentiles) NT-proBNP levels at time of fever and without fever were 378.3 ( 80.2- 1642) and 183 (9- 419.8) ng/L, respectively ( p=0.007). In multiple regression analyses; body temperature, leucocyte count and PCT were found predictive for NT-proBNP levels. (R²=0,456, F=11.987, P<0,001) Conclusion: Despite to the normal cardiac functions, elevated NT- proBNP levels are observed in patients with fever. This situation should be considered in the interpretation of high NT- proBNP levels.

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