ADMET & DMPK

ADMET & DMPK

Rapid Screening of Mupirocin Skin Permeation Modification by Micronized and Nanonized Alaptide

Yazarlar: Radka Opatrilova, Josef Jilek

Cilt 2 , Sayı 1 , 2014 , Sayfalar 56-62

Konular:-

DOI:10.5599/admet.2.1.26

Anahtar Kelimeler:Alaptide,Mupirocin,Nanoparticles,Bactroban®

Özet: The investigation deals with the affection of permeation of mupirocin from the Bactroban® Leciva ointment through full-thickness pig ear skin by alaptide that was applied in micronized or nanonized form as a potential excipient. Alaptide, (S)-8-methyl-6,9-diazaspiro[4.5]decan-7,10-dione, was the original Czech compound. It was discovered that micronized alaptide significantly enhanced the permeation of mupirocin within 1 h after administration (approx. 5-fold). On the other hand, nanonized alaptide almost completely inhibited permeation of mupirocin from Bactroban® Leciva through the skin. Rapid primary screening showed that the two forms of alaptide differently influenced the depth and the rate of permeation/penetration of mupirocin into/through the skin, i.e., affect curative effect of mupirocin on/in skin immediately after application of drug formulation.

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@article{2014, title={Rapid Screening of Mupirocin Skin Permeation Modification by Micronized and Nanonized Alaptide}, volume={2}, number={56–62}, publisher={ADMET & DMPK}, author={Radka Opatrilova, Josef Jilek}, year={2014} }
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Radka Opatrilova, Josef Jilek. (2014). Rapid Screening of Mupirocin Skin Permeation Modification by Micronized and Nanonized Alaptide (Vol. 2). Vol. 2. ADMET & DMPK.
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Radka Opatrilova, Josef Jilek. Rapid Screening of Mupirocin Skin Permeation Modification by Micronized and Nanonized Alaptide. no. 56–62, ADMET & DMPK, 2014.
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