ADMET & DMPK

Yazarlar: Samuel Yalkowsky, Raj Patel, Doaa Al-Antary

Konular:-

DOI:10.5599/admet.3.4.209

Anahtar Kelimeler:-

Özet: A number of publications which challenge the applicability of the Henderson-Hasselbalch equation to saturated solutions have appeared in the last few years (Avdeef [1-3], Butcher et al. [4], and Volgyi et al. [5]). In the most recent of these, Butcher et al. [4] suggested “the Henderson-Hasselbalch equation may not always be an accurate predictor of the pH dependence of solubility.” They claimed that the pKa of 4.70 determined by Jain et al. [6] for NSC-639829 is incorrect and that the value of 3.76, which they obtained by extrapolation of spectrophotometrically determined pKa values in 22, 30, and 41 percent methanol-water solutions, is the correct value. We believe that 4.70 is the correct value and that there are several serious flaws in their analysis. These are described below.

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