ADMET & DMPK

ADMET & DMPK

Dissolution rates of ciprofloxacin and its cocrystal with resorcinol

Yazarlar: Clara Ràfols, Hanan Fael, Elisabet Fuguet, Breeze Outhwaite, Samuel Lee, Rebeca Ruiz

Cilt 6 , Sayı 1 , 2018 , Sayfalar 61-70

Konular:-

DOI:10.5599/admet.6.1.497

Anahtar Kelimeler:Dissolution rate,Cocrystal,Ciprofloxacin,Solid state,FaSSIF,FeSSIF,Simulated gastrointestinal fluid

Özet: The synthesis of cocrystals is presented as an alternative to improve the properties of active pharmaceutical ingredients, especially those related to solubility and dissolution rate. In this work the dissolution rate of ciprofloxacin, a zwitterionic fluoroquinolone antibiotic, has been compared to its cocrystal with resorcinol. To this end, dissolution rate has been determined at several biorelevant pH values, and also in two simulated gastrointestinal fluids (FeSSIF and FaSSIF). Results show that both, ciprofloxacin and the cocrystal, dissolve more slowly as pH increases (from 2.0 to 7.4), as ionization degree of ciprofloxacin decreases. In addition, dissolution is not enhanced by the components of the gastrointestinal fluids.

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@article{2018, title={Dissolution rates of ciprofloxacin and its cocrystal with resorcinol}, volume={6}, number={61–70}, publisher={ADMET & DMPK}, author={Clara Ràfols, Hanan Fael, Elisabet Fuguet, Breeze Outhwaite, Samuel Lee, Rebeca Ruiz}, year={2018} }
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Clara Ràfols, Hanan Fael, Elisabet Fuguet, Breeze Outhwaite, Samuel Lee, Rebeca Ruiz. (2018). Dissolution rates of ciprofloxacin and its cocrystal with resorcinol (Vol. 6). Vol. 6. ADMET & DMPK.
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Clara Ràfols, Hanan Fael, Elisabet Fuguet, Breeze Outhwaite, Samuel Lee, Rebeca Ruiz. Dissolution Rates of Ciprofloxacin and Its Cocrystal with Resorcinol. no. 61–70, ADMET & DMPK, 2018.
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