The Turkish Journal of Vascular Surgery

Yazarlar: Kaan Kırali, Hasan Ekim, Hanefi Özbek, Süleyman Özen

Konular:-

Anahtar Kelimeler:Venous thrombosis,Trombin,Recanalisation,Neovaskularisation

Özet: Acute deep venous thrombosis was developed in rats to assess the relations among the duration of deep vein throm­ bosis, neovascular growths and thrombolysis. Both femoral veins of 20 male Sprague-Dawley rats were dissected. Right femoral veins served as control group. The left femoral veins were proximally obstructed to cause thrombosis. Obstruction was achieved either by means of pro­ ximal suture ligation in the 1O rats (Group 1) or by means of clip ligation. Clip was removed in 5 rats after 24 hours (Group 2A) and in the remaining 5 rats after 72 hours (Group 2B). Group 1 and Group 2B veins had marked vein wall thickening consisting of smooth muscle type, neointimal and cel­ lular proliferation peaking between 7 and 15 days. Within 15-18 days, neovascular groW1hs we re observed, and re­ sumption of normal venous flow was seen to bypass the obstructed segment. Subsequently, neointimal proliferation regressed, but medial cellular growth persisted. in contrast, group 2A veins had no neovascular changes and early thrombosis extension was seen (within 8 days). Within 15 days, Group 2A veins regained normal appearance and resumed normal flow. Thrombosis with chronic venous otııstruction results in early•extension of thrombus, delayed re-canalization, develop­ ment of neovascular channels and permanent proliferative changes.

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