The Turkish Journal of Vascular Surgery

Yazarlar: Hüseyin OKUTAN, Erol EROĞLU, Nermin KARAHAN, Asım AYDIN, Bahattin TUNÇ, Özden ÇANDIR, Ali KUTSAL

Konular:-

Anahtar Kelimeler:Heparin,Low-molecular-weight-heparin,Rat,Vena cava

Özet: Purpose: Venous thrombosis has been demonstrated to be associated with vein wall inflammation. Anti-inflammatory effects of standard heparin (SH) and low-molecular-weight heparins (LMWH) are already known. Their anti-inflammatory properties were compared. Methods: Rats were randomly distributed to five groups (n: 8, each) and underwent inferior vena cava (IVC) occlusion just below the renal vein producing IVC thrombosis. One hour before IVC occlusion, the animals were subcutaneously applied with Saline (0.5ml), SH (300U/kg), dalteparin (120U/kg), enoxoparin (100U/kg) and, nadroparin (190U/kg), respectively. Six hours after IVC occlusion, 2 cc blood was drawn for analysis of anti-thrombotic activity, and IVCs were harvested for histopathologic evaluation of inflammatory activity. Results: APTT was almost 3 times higher in SH group (64.77±6.31) compared to the other groups. Anti-factor Xa activity was higher in the all LMWH groups (dalteparin, 1.31±0.01; enoxaparin, 1.32±0.01; nadroparin, 1.29±0.04) compared to SH and NS groups. Neutrophil counts were significantly lower in all prophylacy groups compared to the control group and in LMWH groups compared to SH group. There were no differences in monocyte and lymphocyte counts among groups. Conclusion: Both SH and LMWHs diminished acute inflammation in terms of early neutrophil infiltration into the vein wall when they are applied one hour before the insult inciting venous thrombosis. We believe that, these heparins have similar antiinflammatory properties. (Turkish J Vasc Surg 2004,13(2): 17-22)

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