The Turkish Journal of Vascular Surgery

Yazarlar: Burak Erdolu, Mesut Engin

Konular:-

Anahtar Kelimeler:Carotid artery stenosis,Cerebrovascular event,Lymphocyte,Mean platelet volume

Özet: Objectives: In this study, we aimed to investigate the effect of mean platelet volume-to-lymphocyte ratio (MPVLR) on symptom onset in patients with moderate carotid artery stenosis (CAS). Patients and methods: Between January 2016 and January 2018, a total of 294 patients (178 males, 116 females, mean age 57.9±9.1 years; range, 44 to 81 years) diagnosed with moderate CAS were retrospectively analyzed. The patients were divided into two groups according to their symptomatology as Group 1 (n=238) including asymptomatic patients and Group 2 (n=56) including symptomatic patients. The diagnosis of CAS was made using carotid angiography. The degree of stenosis was determined. The MPVLR was evaluated. Results: The mean age was 53.6±8.5 years in Group 1 and 64.9±9.7 years in Group 2 (p<0.001). In the multivariate analysis, advanced age (odds ratio [OR]: 1.235, 95% confidence interval [CI]: 1.204-1.738, p=0.012), hypertension (OR: 1.030, 95% CI: 1.007-1.552, p=0.037), and MPVLR (OR: 2.156, 95% CI: 1.932-3.116, p=0.005) were found to be independent predictors of the symptom onset. The receiver operating characteristics analysis revealed that the cut-off value for MPVLR was 5.48 (area under the curve [AUC]=0.694, 95% CI: 0.563-0.806, p=0.008) with 69.7% sensitivity and 51.2% specificity. Conclusion: Our study results show that the high MPVLR value, which is a cheap parameter that can be calculated easily, can be used as a promising parameter of CAS symptoms for clinicians.

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