Turkish Journal of Veterinary and Animal Sciences

Turkish Journal of Veterinary and Animal Sciences

The Effects on Myocardial Improvement Using ATP-MgCl2 during the Ischemia Reperfusion Period; An In Vitro Study

Yazarlar: Nusret APAYDIN, Zülfikar Kadir SARITAŞ, Kamuran PAMUK, Eser ÖZGENCİL, Fulya OCAK, Tulga ULUS, Baran BUDAK, Selçuk SÜRÜCÜ, Salih Fehmi KATIRCIOĞLU

Cilt 30 , Sayı 5 , 2006 , Sayfalar 449 - 456

Konular:-

Anahtar Kelimeler:In vitro perfusion,Ischemia-reperfusion damage,Myocardium,ATP-MgCl2

Özet: We investigated the effect of ATP-MgCl2 on myocardial hemodynamics and ultrastructure. In the in vitro study, left ventricular systolic and diastolic pressures and dp/dt values were significantly high in the ATP-MgCl2 group beginning from 0.5 h of the reperfusion period. In the ATP-MgCl2 group, at the end of the third hour, systolic and diastolic pressure values were 80.0 ± 6.2 and 75.2 ± 7.2 mmHg, while in the control group they were 18.4 ± 7.7 and 7.5 ± 6.8 mmHg (P < 0.05). In the ultrastructural analysis, myofibrillary damage was observed in both groups, but the mitochondrial pathologic changes were clearer in the control group. The electron microscopic score was 0.40 ± 0.061 in the ATP-MgCl2 group and 1.2 ± 0.039 in the control group (P < 0.001). The hemodynamic and ultrastructural parameters of the specimens investigated in this study revealed that the usage of ATP-MgCl2 may be beneficial in coping with ischemia-reperfusion damage. In the near future, with the help of more comprehensive studies, ATP-MgCl2 is expected to be used routinely because of its potential benefits.

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@article{2006, title={The Effects on Myocardial Improvement Using ATP-MgCl2 during the Ischemia Reperfusion Period; An In Vitro Study}, volume={30}, number={5}, publisher={Turkish Journal of Veterinary and Animal Sciences}, author={Nusret APAYDIN,Zülfikar Kadir SARITAŞ,Kamuran PAMUK,Eser ÖZGENCİL,Fulya OCAK,Tulga ULUS,Baran BUDAK,Selçuk SÜRÜCÜ,Salih Fehmi KATIRCIOĞLU}, year={2006}, pages={449–456} }
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Nusret APAYDIN,Zülfikar Kadir SARITAŞ,Kamuran PAMUK,Eser ÖZGENCİL,Fulya OCAK,Tulga ULUS,Baran BUDAK,Selçuk SÜRÜCÜ,Salih Fehmi KATIRCIOĞLU. (2006). The Effects on Myocardial Improvement Using ATP-MgCl2 during the Ischemia Reperfusion Period; An In Vitro Study (Vol. 30, pp. 449–456). Vol. 30, pp. 449–456. Turkish Journal of Veterinary and Animal Sciences.
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Nusret APAYDIN,Zülfikar Kadir SARITAŞ,Kamuran PAMUK,Eser ÖZGENCİL,Fulya OCAK,Tulga ULUS,Baran BUDAK,Selçuk SÜRÜCÜ,Salih Fehmi KATIRCIOĞLU. The Effects on Myocardial Improvement Using ATP-MgCl2 during the Ischemia Reperfusion Period; An In Vitro Study. no. 5, Turkish Journal of Veterinary and Animal Sciences, 2006, pp. 449–56.
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