Records of Natural Products

Yazarlar: Nasser A. Awadh Ali, Martina Wurster, Norbert Arnold, Axel Teichert, Jürgen Schmidt, Ulrike Lindequist Ludger Wessjohann

Konular:-

Anahtar Kelimeler:Essential oils,Boswellia,GC-MS,Antioxidant,AchE inhibitor,Soqotra

Özet: The chemical composition, antioxidant and anticholinesterase activity of three essential oils (EOs) obtained from the oleogum resin of three endemic Sqotraen Boswellia species, Boswellia socotrana Balf. f, Boswellia ameero Balf. f, andBoswellia elongata Balf. f were determined. GC-MS technique was used for the analysis of the oils. Oils of B. socotrana and B. ameero were characterized by a high content of monoterpenes. The main constituens of B. socotrana and B. ameero were (E)-2,3-epoxycarene (51.8%), 1,5-isopropyl-2-methylbicyclo[3.1.0]hex-3-en-2-ol (31.3%), and a -cymene (7.1%); (3E,5E)-2,6-dimethyl-1,3,5,7-octatetraene (34.9%), 1-(2,4-Dimethylphenyl)ethanol (20.3%), 3,4-dimethylstyrene (17.3%), a -campholenal (13.4%) and a -terpineol (12.4%) respectively. The composition of B. elongata oil was dominated by the diterpene verticiol (52.4%), the sesquiterpene caryophellene (39.1%) and methylcycloundecanecarboxylate (7.8%). The oils were screened for their antioxidant activity by using the DPPH free radical scavenger assay and their anticholinesterase activity on acetylcholinesterase enzyme by using in vitro Ellman method. The antioxidant activity of EOs from B. socotrana (IC 50 =121.4 µg/mL) appeared to be more potent than that of B. elongata (IC 50 =211.2 µg/mL) and B. ameero (IC 50 =175.2 µg/mL). EO of B. socotrana showed the higher AChE inhibitory activity with 59.3% at concentration of 200 μ g/mL in comparison to EOs of B. elongata and B. ameero (29.6, 41.6 enzyme inhibition) respectively.

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