Records of Natural Products

Records of Natural Products

Antiproliferative effect from sesquiterpene lactone s of Carpesium rosulatum MlQ consumed in South Korea on the five human cancer cell lines

Yazarlar: Hyung-In Moon Okpyo Zee

Cilt 4 , Sayı 3 , 2010 , Sayfalar 149 - 155

Konular:-

Anahtar Kelimeler:Carpesium rosulatum,Cytotoxic activity,Human tumor cell lines,SRB .

Özet: In search for antiproliferative compound against human cancer cells (A549, SK-OV-3, SK-MEL-2, XF498, HCT15), a chloroform soluble extract obtained by re-extraction of the methanol extract of whole plant of Carpesium rosulatum MlQ. (Compositae) exhibited cytotoxic activity. Four germacrane sesquiterpene lactones 2α,5-epoxy-5,10-dihydroxy-6-angeloyl-oxy-9β-isobutyloxy-germacran-8α,12-olide, 2α,5-epoxy-5,10-dihydroxy-6α,9β-diangeloyloxy-germacran-8α,12-olide, 2α,5-epoxy-5,10-dihydroxy-6α-angeloyloxy-9β-(3-methyl-butanoyloxy)-germacran-8α,12-olide, and 2β,5-epoxy-5,10-dihydroxy-6α,9β-diangeloyloxy-germacran-8α,12-olide were isolated from the chloroform extract of C . rosulatum, and 2α,5-epoxy-5,10-dihydroxy-6α,9β-diangeloyloxy-germacran-8α,12-olide showed the most potent cytotoxicity with IC 50 value of 6.01 μM against SK-MEL-2 .

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@article{2010, title={Antiproliferative effect from sesquiterpene lactone s of Carpesium rosulatum MlQ consumed in South Korea on the five human cancer cell lines}, volume={4}, number={149–155}, publisher={Records of Natural Products}, author={Hyung-In Moon  Okpyo Zee}, year={2010} }
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Hyung-In Moon  Okpyo Zee. (2010). Antiproliferative effect from sesquiterpene lactone s of Carpesium rosulatum MlQ consumed in South Korea on the five human cancer cell lines (Vol. 4). Vol. 4. Records of Natural Products.
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Hyung-In Moon  Okpyo Zee. Antiproliferative Effect from Sesquiterpene Lactone s of Carpesium Rosulatum MlQ Consumed in South Korea on the Five Human Cancer Cell Lines. no. 149–155, Records of Natural Products, 2010.
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