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Records of Natural Products
Yazarlar: Meena Rajbhari, Michael Lalk, Renate Mentel Ulrike Lindequist
Konular:-
Anahtar Kelimeler:Astilbe rivularis ,Antiviral,Arbutin,Bergenin,Dimer of bergenin.
Özet: During the screening of Nepalese ethnomedicinal plants for antiviral activities, Astilbe rivularis Buch.-Ham. , Saxifragaceae, was identified as a promising species. Bioassay-guided fractionation led to the isolation of arbutin, bergenin and a bergenin derivative. The structures were established by NMR studies. Except bergenin, the two compounds were found in this plant for the first time. A dimer of bergenin has not been described as a natural product before. The compounds showed in vitro antiviral activity against herpes simplex virus type-1 in non cytotoxic concentrations.