Records of Natural Products

Records of Natural Products

Cytotoxic Activity of β -Caryophyllene Oxide Isolated from Jeju Guava (Psidium cattleianum Sabine) Leaf

Yazarlar: Neung Jae Jun, Ashik Mosaddik, Jeong Yong Moon, Ki-Chang Jang, Dong-Sun Lee, Kwang Seok Ahn Somi K. Cho

Cilt 5 , Sayı 3 , 2011 , Sayfalar 242 - 246

Konular:-

Anahtar Kelimeler:Β-caryophyllene oxide,Cytotoxicity,Jeju guava,Psidium cattleianum

Özet:  β -caryophyllene oxide was isolated from the leaf of the Jeju guava (Psidium cattleianum Sabine) for the first time in this study. The chemical structure was confirmed with the help of various spectroscopic analyses, including NMR data, by comparison to that of the published data. An MTT assay was conducted against several cancer cell lines t o resolve an ongoing controversy regarding the cytotoxic effects of β-caryophyllene oxide. β-caryophyllene oxide evidenced potent cytotoxic activity against HepG2, AGS, HeLa, SNU-1, and SNU-16 cells, with IC 50 values of 3.95, 12.6, 13.55, 16.79, and 27.39 μM, respectively. The results also showed that β-caryophyllene oxide evidenced cytotoxicity in both a dose-dependent and time-dependent manner.


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KAYNAK GÖSTER
BibTex
KOPYALA
@article{2011, title={Cytotoxic Activity of β -Caryophyllene Oxide Isolated from Jeju Guava (Psidium cattleianum Sabine) Leaf}, volume={5}, number={242–246}, publisher={Records of Natural Products}, author={Neung Jae Jun, Ashik Mosaddik, Jeong Yong Moon, Ki-Chang Jang, Dong-Sun Lee, Kwang Seok Ahn  Somi K. Cho}, year={2011} }
APA
KOPYALA
Neung Jae Jun, Ashik Mosaddik, Jeong Yong Moon, Ki-Chang Jang, Dong-Sun Lee, Kwang Seok Ahn  Somi K. Cho. (2011). Cytotoxic Activity of β -Caryophyllene Oxide Isolated from Jeju Guava (Psidium cattleianum Sabine) Leaf (Vol. 5). Vol. 5. Records of Natural Products.
MLA
KOPYALA
Neung Jae Jun, Ashik Mosaddik, Jeong Yong Moon, Ki-Chang Jang, Dong-Sun Lee, Kwang Seok Ahn  Somi K. Cho. Cytotoxic Activity of β -Caryophyllene Oxide Isolated from Jeju Guava (Psidium Cattleianum Sabine) Leaf. no. 242–246, Records of Natural Products, 2011.