Records of Natural Products

Records of Natural Products

Synthesis and Myocardial Ischemia Protective Effect of Ocotillol-Type Derivatives

Yazarlar: Bi Yi, Wang Tian, Meng Qingguo, Zhang Jiangfen, Wang Liang, Li Qiang, Zhao Fenglan Sun Haijun

Cilt 6 , Sayı 3 , 2012 , Sayfalar 242 - 254

Konular:-

Anahtar Kelimeler:Ocotillol-type derivatives,Myocardial ischemia,Synthesis,Ginsenoside.

Özet: A series of ocotillol-type derivatives bearing a glycosyl moiety were synthesized. Among them, compound 3a and 3b led to a reduction in the increased CK, LDH, MDA activity and attenuate the decrease of SOD, GSH-PX and T-AOC compared with the iso group. In the heart section, compound 3aand 3b group showed nearly normal myofibrillar structure nearly without neutrophil granulocytes infiltration in the iso group. These results indicated that ocotillol-type derivatives may be the good lead compounds with protective property of myocardial ischemia.

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@article{2012, title={Synthesis and Myocardial Ischemia Protective Effect of Ocotillol-Type Derivatives}, volume={6}, number={242–254}, publisher={Records of Natural Products}, author={Bi Yi, Wang Tian, Meng Qingguo, Zhang Jiangfen, Wang Liang, Li Qiang, Zhao Fenglan  Sun Haijun}, year={2012} }
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Bi Yi, Wang Tian, Meng Qingguo, Zhang Jiangfen, Wang Liang, Li Qiang, Zhao Fenglan  Sun Haijun. (2012). Synthesis and Myocardial Ischemia Protective Effect of Ocotillol-Type Derivatives (Vol. 6). Vol. 6. Records of Natural Products.
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Bi Yi, Wang Tian, Meng Qingguo, Zhang Jiangfen, Wang Liang, Li Qiang, Zhao Fenglan  Sun Haijun. Synthesis and Myocardial Ischemia Protective Effect of Ocotillol-Type Derivatives. no. 242–254, Records of Natural Products, 2012.
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