Records of Natural Products

Records of Natural Products

Chemical Constituents from the Roots of Clausena excavata and Their Cytotoxicity

Yazarlar: Tawanun Sripisut, Sarot Cheenpracha, Thunwadee Ritthiwigrom, Uma Prawat, Surat Laphookhieo

Cilt 6 , Sayı 4 , 2012 , Sayfalar 386 - 389

Konular:-

Anahtar Kelimeler:Clausena excavata ,Rutaceae,Coumarins,Alkaloids,Cytotoxicity.

Özet: Six coumarins (1-6) and twelve alkaloids (7-18) were isolated from the roots of Clausena excavata. Their structures were elucidated on the basis of spectroscopic methods. This is the first report on the isolation of compounds 1, 7 and 17 from C. excavata. Compound 1 is also the first example of an unsymmetrical dimer coumarin isolated from Clausena species. The completed assignment of 13C NMR spectral data of 1 as well as HMBC spectral data is also reported here for the first time. Compounds 2-7, 11-16 and 18 were evaluated for their cytotoxicity against three human cancer cell lines, oral cavity cancer (KB), breast cancer (MCF7) and small cell lung cancer (NCI-H187). The results showed that compounds 4, 11 and 18 exhibited highest cytotoxicity against KB, MCF7 and NCI-H187 cell lines with IC 50 values of 5.95, 3.76 and 5.65 µg/mL, respectively.

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@article{2012, title={Chemical Constituents from the Roots of Clausena excavata and Their Cytotoxicity}, volume={6}, number={386–389}, publisher={Records of Natural Products}, author={Tawanun Sripisut, Sarot Cheenpracha, Thunwadee Ritthiwigrom, Uma Prawat, Surat Laphookhieo}, year={2012} }
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Tawanun Sripisut, Sarot Cheenpracha, Thunwadee Ritthiwigrom, Uma Prawat, Surat Laphookhieo. (2012). Chemical Constituents from the Roots of Clausena excavata and Their Cytotoxicity (Vol. 6). Vol. 6. Records of Natural Products.
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Tawanun Sripisut, Sarot Cheenpracha, Thunwadee Ritthiwigrom, Uma Prawat, Surat Laphookhieo. Chemical Constituents from the Roots of Clausena Excavata and Their Cytotoxicity. no. 386–389, Records of Natural Products, 2012.
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