Records of Natural Products

Yazarlar: Ozlem Demirkiran, M. Ahmad Mesaik, Hayrettin Beynek, Ahmed Abbaskhan M. Iqbal Choudhary

Konular:-

Anahtar Kelimeler:Hypericum monbretii Spach.,Phenolics,Immunomodulating inhibitory activity,Reactive oxygen species,T-cell proliferation,IL-2 production.

Özet:  The MeOH extract of aerial parts of H. monbretii Spach. have yielded quercetin (1), kaempferol (2), quercitrin (3), hyperin (4), myricitrin (5), rutin (6), I 3 II 8′′ biapigenin (7), methyl chlorogenate (8), 5-O-p-coumaroylquinic acid (9), and chlorogenic acid (5-O-caffeoyl quinic acid) (10), mangiferin (11), and shikimic acid (12). Three compounds 1, 2 and 4 were found to have an immunomodulating inhibitory activity on the oxidative burst response of human neutrophils, as well on mouse peritoneal macrophages. E ffects of compounds on whole blood phagocytes activity was found to be with IC 50 ranging between 8.0-12.2 µg/mL. O nly compounds 1, and 2 were found to interfere with T-cell proliferation, and IL-2 release in PHA activated peripheral blood mononuclear cells system. To the best of our knowledge, this is the first report of phytochemical and biological activity study on H. montbretii Spach.

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