Records of Natural Products

Records of Natural Products

Synthesis and Antitumor Activity of 17-carboxylic acid M odified A mide D erivatives of 3-hydroxy betulinic acid

Yazarlar: Yi Bi, Jin -Y i Xu, Fei Sun, Xiao -M ing Wu, Wen -C ai Y e, Yi -J un Sun, Qing -G uo Meng Wen -W en Huang

Cilt 7 , Sayı 4 , 2013 , Sayfalar 254 - 265

Konular:-

Anahtar Kelimeler:23-hydroxy betulinic acid ,Amide derivatives ,Structure modification ,Antitumor activity ,Structure-activity relationship .

Özet:  A novel series of 17-carboxylic acid modified amide derivatives of 3-hydroxy betulinic acid (1) were prepared and tested in vitro against five cell lines: A549 (human lung carcinoma), BEL-7402 (human hepatoma), SF-763 (human cerebroma), B16 (mice melanoma) and HL-60 (human leukaemia) . Within this series of compounds, 4a (IC 50=21.08 μ M in SF-763, IC 50=21.63 μ M in HL-60), 4b (IC 50=28.45 μ M in HL-60,IC 50=29.32 μ M in BEL-7402 ) and 6g (IC 50=26.09 μM in BEL-7402, IC 50=22.65 μM in HL-60) have the mo re potent cytotoxic activity than lead compound 1. The preliminary structure-activity relationship analysis of the C-28 amide derivatives is also discussed.

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@article{2013, title={Synthesis and Antitumor Activity of 17-carboxylic acid M odified A mide D erivatives of 3-hydroxy betulinic acid}, volume={7}, number={254–265}, publisher={Records of Natural Products}, author={Yi Bi, Jin -Y i Xu, Fei Sun, Xiao -M ing Wu, Wen -C ai Y e, Yi -J un Sun, Qing -G uo Meng  Wen -W en Huang}, year={2013} }
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Yi Bi, Jin -Y i Xu, Fei Sun, Xiao -M ing Wu, Wen -C ai Y e, Yi -J un Sun, Qing -G uo Meng  Wen -W en Huang. (2013). Synthesis and Antitumor Activity of 17-carboxylic acid M odified A mide D erivatives of 3-hydroxy betulinic acid (Vol. 7). Vol. 7. Records of Natural Products.
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Yi Bi, Jin -Y i Xu, Fei Sun, Xiao -M ing Wu, Wen -C ai Y e, Yi -J un Sun, Qing -G uo Meng  Wen -W en Huang. Synthesis and Antitumor Activity of 17-Carboxylic Acid M Odified A Mide D Erivatives of 3-Hydroxy Betulinic Acid. no. 254–265, Records of Natural Products, 2013.
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