Records of Natural Products

Yazarlar: Ratchanaporn Chokchaisiri, Prapapan Pimkaew, Pawinee Piyachaturawat, Rattana Chalermglin Apichart Suksamrarn

Konular:-

Anahtar Kelimeler:Curcuma elata ,Zingiberaceae,Sesquiterpenoids ,Diarylheptanoids,Cytotoxicity . © 2014 ACG Publications. All rights reserved.

Özet: The present study was aimed to investigate the chemical constituents of Curcuma elata Roxb. (Zingiberaceae) rhizomes originating in Thailand. Ten sesquiterpenes, germacrone (1), curzerenone (2), isofuranodienone (3), furanodienone (4), curdione (5), neocurdione (6), zederone (7), curcumenone (8), 13- hydroxygermacrone (9) and zedoarondiol (10), and four diarylheptanoids, 3-hydroxy- 5-platyphyllone (11), (3S)-1,7-bis(4-hydroxyphenyl)-(6E)-6-hepten-3-ol (12), centrolobol (13) and (3 S )- 1- (3,4-dihydroxyphenyl)-7-(4-hydroxyphenyl)-(6E)-6-hepten-3-ol (14) were isolated for the first time from the rhizomes of this plant. The structures of the isolated compounds were identified by comparison of the spectroscopic and physical data with those of the reported values and the stereochemistry at the asymmetric carbon was determined by the modified Mosher’s method and, in some cases, was confirmed by comparison of optical rotation data with literature. Compounds 12 and 13 exhibited strong cytotoxic activity against KB cell line, whereas compounds 4, 9and 12-14 showed strong cytoxicity against NCI-H187 cell line.

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