Records of Natural Products

Records of Natural Products

Petasins from the R hizomes of Ligularia fischeri and I ts D erivatives

Yazarlar: Caifang Wang, Junping Li, Ru Yang, Yuan Zhao, Yuefang Cheng, Zhenzhong Zhang Lan He

Cilt 8 , Sayı 2 , 2014 , Sayfalar 156 - 164

Konular:-

Anahtar Kelimeler:Ligularia fischeri ,Sesquiterpenoids,Isolation and structural modification,Single crystal X-ray diffraction. © 2014 ACG Publications. All rights reserved.

Özet: Five eremophilane sesquiterpenoids were isolated from the rhizomes of Ligularia fischeri grown in Henan province of China and identified as 3α-Tigloyloxyeremophila-9,11-dien-8-one (3), Isopetasan (4), Neopetasan (5), Isopetasol(6) and Petasol (7), by spectroscopic methods. Petasin (1) previously isolated was analyzed to determine its absolute configuration by X-ray single crystal diffraction. Five petasin derivatives including three new compounds (2a, 6a and 6b) were synthesized. 12 eremophilane sesquiterpenoids including the derivatives except for 4 (minor amount) were assessed against human neuroblastoma (SKN-SH) by the SRB method. 1 was also tested on inhibiting prostate carcinoma (Bc3) cell lines. The results showed 1 has the strong inhibitory activity against SKN-SH and Bc3 cell lines and other compounds with α-isopropylidene group also have the strong activity against the human neuroblastoma (SKN-SH). The above results indicated the α - isopropylidene group might be the active center against pulmonary carcinoma (SKN-SH) in the same eremophilane-type skeleton. Petasins may be interesting for their good bioactivities.


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BibTex
KOPYALA
@article{2014, title={Petasins from the R hizomes of Ligularia fischeri and I ts D erivatives}, volume={8}, number={156–164}, publisher={Records of Natural Products}, author={Caifang Wang, Junping Li, Ru Yang, Yuan Zhao, Yuefang Cheng, Zhenzhong Zhang  Lan He}, year={2014} }
APA
KOPYALA
Caifang Wang, Junping Li, Ru Yang, Yuan Zhao, Yuefang Cheng, Zhenzhong Zhang  Lan He. (2014). Petasins from the R hizomes of Ligularia fischeri and I ts D erivatives (Vol. 8). Vol. 8. Records of Natural Products.
MLA
KOPYALA
Caifang Wang, Junping Li, Ru Yang, Yuan Zhao, Yuefang Cheng, Zhenzhong Zhang  Lan He. Petasins from the R Hizomes of Ligularia Fischeri and I Ts D Erivatives. no. 156–164, Records of Natural Products, 2014.