Records of Natural Products

Records of Natural Products

New Cyclolignans from Origanumglandulosum Active Against b -amyloid Aggregation

Yazarlar: Abdelkader Basli, Jean-Claude Delaunay, Eric Pet, Stéphane Bernillon, Khodir Madani, Jean-Pierre Monti, Jean Michel Mérillon, Mohamed Chibane, Tristan Richard

Cilt 8 , Sayı 3 , 2014 , Sayfalar 208 - 216

Konular:-

Anahtar Kelimeler:Origanum glandulosum ,Oregano,Cyclolignans,Β-Amyloid aggregation,NMR.

Özet: Origanum glandulosum Desf is an endemic flavoring herb widely distributed in North Africa that is commonly used in traditional medicine. This oregano species is rich in essential oils but little is known about its phenolic composition. In the present study, a crude extract of O. glandulosum was prepared in order to isolate and investigate its neuroprotective potential to inhibit β-amyloid peptide (Aβ) aggregation. The three major compounds of the extract were isolated: rosmarinic acid and two cyclolignans in Origanum genus, globoidnan A and a new derivative named globoidnan B. Rosmarinic acid and globoidnan A showed significant anti-aggregative activity against β amyloid aggregation (IC50 7.0 and 12.0 µM, respectively). In contrast, globoidnan B was found to be less active

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@article{2014, title={New Cyclolignans from Origanumglandulosum Active Against b -amyloid Aggregation}, volume={8}, number={208–216}, publisher={Records of Natural Products}, author={Abdelkader Basli, Jean-Claude Delaunay, Eric Pedrot, Stéphane Bernillon, Khodir Madani, Jean-Pierre Monti, Jean Michel Mérillon, Mohamed Chibane, Tristan Richard}, year={2014} }
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Abdelkader Basli, Jean-Claude Delaunay, Eric Pedrot, Stéphane Bernillon, Khodir Madani, Jean-Pierre Monti, Jean Michel Mérillon, Mohamed Chibane, Tristan Richard. (2014). New Cyclolignans from Origanumglandulosum Active Against b -amyloid Aggregation (Vol. 8). Vol. 8. Records of Natural Products.
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Abdelkader Basli, Jean-Claude Delaunay, Eric Pedrot, Stéphane Bernillon, Khodir Madani, Jean-Pierre Monti, Jean Michel Mérillon, Mohamed Chibane, Tristan Richard. New Cyclolignans from Origanumglandulosum Active Against b -Amyloid Aggregation. no. 208–216, Records of Natural Products, 2014.
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