Records of Natural Products

Records of Natural Products

Adulteration Determining of Pharmaceutical Forms of Ginkgo biloba Extracts from Different International Manufacturers

Yazarlar: L. Ömür Demirezer , Aslı Büyükkaya, Ebru Uçaktürk, Ayşe Kuruüzüm-Uz, Zuhal Güvenalp Erhan Palaska

Cilt 8 , Sayı 4 , 2014 , Sayfalar 394 - 400

Konular:-

Anahtar Kelimeler:Ginkgo biloba ,Fingerprint analysis,Flavonoids,Diterpene lactone,LC-MS,HPLC-DAD.

Özet: In this study, Ginkgo biloba products used for the same purpose, but licensed to varying authorities were analyzed in point of similarity to each other. A group of these products were licensed from health authorities as herbal medicinal product (HMP), while the other groups of products were licensed as the food supplement (FS). The evaluation of their phytoequivalence was carried out comparing the chromatographic fingerprint profiles. Furthermore, ginkgolides (ginkgolides GA, GB, GC, and GJ) and flavonoid aglycones (quercetin, kaempferol, and isorhamnetin) were quantitatively analyzed by using liquid chromatography–mass spectrometry (LC-MS) and HPLC-diode Array detector (HPLC-DAD) assays. All six herbal medicinal products and two food supplements were found to be phytoequivalent to each other, but five of the seven food supplements did not possess similar content as herbal medicinal products, and the quantity of ginkgolides and flavonoid aglycones per tablet/capsule was found to be lower than declared on the labels. In addition, food supplements were found to be adultered with rutin to reach expected total flavonoid glycosides amount.

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@article{2014, title={Adulteration Determining of Pharmaceutical Forms of Ginkgo biloba Extracts from Different International Manufacturers}, volume={8}, number={394–400}, publisher={Records of Natural Products}, author={L. Ömür Demirezer , Aslı Büyükkaya, Ebru Uçaktürk, Ayşe Kuruüzüm-Uz, Zuhal Güvenalp  Erhan Palaska}, year={2014} }
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L. Ömür Demirezer , Aslı Büyükkaya, Ebru Uçaktürk, Ayşe Kuruüzüm-Uz, Zuhal Güvenalp  Erhan Palaska. (2014). Adulteration Determining of Pharmaceutical Forms of Ginkgo biloba Extracts from Different International Manufacturers (Vol. 8). Vol. 8. Records of Natural Products.
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L. Ömür Demirezer , Aslı Büyükkaya, Ebru Uçaktürk, Ayşe Kuruüzüm-Uz, Zuhal Güvenalp  Erhan Palaska. Adulteration Determining of Pharmaceutical Forms of Ginkgo Biloba Extracts from Different International Manufacturers. no. 394–400, Records of Natural Products, 2014.
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