Records of Natural Products

Records of Natural Products

Anticancer and Alkaline Phosphatase Inhibitory Effects of Compounds Isolated from the Leaves of Olea ferruginea Royle

Yazarlar: Muhammad Ali Hashmi, Hamid Saeed Shah, Afsar Khan, Umar Farooq, Jamshed Iqbal, Viqar Uddin Ahmad Shagufta Perveen

Cilt 9 , Sayı 1 , 2015 , Sayfalar 164 - 168

Konular:-

Anahtar Kelimeler:Olea,Olea ferruginea,Secoiridoid,Anticancer,Flavonoid

Özet: One flavonoid, one ursane type triterpene, and two seco-iridoids were isolated from the leaves of Olea ferruginea Royle. The compounds were screened against TNALP and CIALP enzymes for their in vitro alkaline phosphatase inhibitory studies and HeLa cancer cell lines to measure their anticancer potential. Compound 1 showed the highest activity of 89.5 ± 1.5 nM against CIALP enzyme. All the compounds showed little activity against TNALP enzyme which shows the specificity of these compounds for CIALP enzyme only. Compounds 1, 3 , and 4 exhibited anticancer activity comparable to the reference drug vincristine (VNCT). All the compounds showed minimum toxicity against vero cells at 10 μM concentration.

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@article{2015, title={Anticancer and Alkaline Phosphatase Inhibitory Effects of Compounds Isolated from the Leaves of Olea ferruginea Royle}, volume={9}, number={164–168}, publisher={Records of Natural Products}, author={Muhammad Ali Hashmi, Hamid Saeed Shah, Afsar Khan,*, Umar Farooq, Jamshed Iqbal, Viqar Uddin Ahmad  Shagufta Perveen}, year={2015} }
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Muhammad Ali Hashmi, Hamid Saeed Shah, Afsar Khan,*, Umar Farooq, Jamshed Iqbal, Viqar Uddin Ahmad  Shagufta Perveen. (2015). Anticancer and Alkaline Phosphatase Inhibitory Effects of Compounds Isolated from the Leaves of Olea ferruginea Royle (Vol. 9). Vol. 9. Records of Natural Products.
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Muhammad Ali Hashmi, Hamid Saeed Shah, Afsar Khan,*, Umar Farooq, Jamshed Iqbal, Viqar Uddin Ahmad  Shagufta Perveen. Anticancer and Alkaline Phosphatase Inhibitory Effects of Compounds Isolated from the Leaves of Olea Ferruginea Royle. no. 164–168, Records of Natural Products, 2015.
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