Records of Natural Products

Records of Natural Products

Identification of Highly Potent and Selective α-Glucosidase Inhibitors with Antiglycation Potential, Isolated from Rhododendron arboreum

Yazarlar: Rabia Raza, Zaitoon Ilyas, Sajid Ali, Muhammad Nisar, Muhammad Younas Khokhar Jamshed Iqbal

Cilt 9 , Sayı 2 , 2015 , Sayfalar 262 - 266

Konular:-

Anahtar Kelimeler:Rhododendron arboreum,Α-glucosidase inhibitors,Antidiabetic,Antiglycation

Özet: This study explored antidiabetic potential of eight known pure compounds, isolated from the bark of Rhododendron arboreum. Invitro studies of these compounds against α and β-glucosidases revealed them as very potent and selective inhibitors of α-glucosidase. Compound 7 (3-O-acetylursolic acid) was found to be the most potent inhibitor of α-glucosidase with 3.3±0.1µM IC 50 value which was many folds higher than standard inhibitor acarbose. Antiglycation studies of compounds showed that all compounds were also very active antiglycation agents. The studied biological properties of these compounds suggest that they are therapeutically interesting and important tools for treatment of diabetes.

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@article{2015, title={Identification of Highly Potent and Selective α-Glucosidase Inhibitors with Antiglycation Potential, Isolated from Rhododendron arboreum}, volume={9}, number={262–266}, publisher={Records of Natural Products}, author={Rabia Raza, Zaitoon Ilyas, Sajid Ali, Muhammad Nisar, Muhammad Younas Khokhar  Jamshed Iqbal}, year={2015} }
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Rabia Raza, Zaitoon Ilyas, Sajid Ali, Muhammad Nisar, Muhammad Younas Khokhar  Jamshed Iqbal. (2015). Identification of Highly Potent and Selective α-Glucosidase Inhibitors with Antiglycation Potential, Isolated from Rhododendron arboreum (Vol. 9). Vol. 9. Records of Natural Products.
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Rabia Raza, Zaitoon Ilyas, Sajid Ali, Muhammad Nisar, Muhammad Younas Khokhar  Jamshed Iqbal. Identification of Highly Potent and Selective α-Glucosidase Inhibitors with Antiglycation Potential, Isolated from Rhododendron Arboreum. no. 262–266, Records of Natural Products, 2015.
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