Records of Natural Products

Records of Natural Products

Anti-Mycobacterium tuberculosis Active Metabolites from an Endophytic Streptomyces sp. YIM65484

Yazarlar: Hao Zhou, Lixing Zhao, Wei Li, Yabin Yang, Lihua Xu Zhongtao Ding

Cilt 9 , Sayı 2 , 2015 , Sayfalar 196 - 200

Konular:-

Anahtar Kelimeler:Streptomyces sp.,Anti- M. tuberculosis,Phenylpentadienamide

Özet: In our screening for antitubercular leading compounds, an endophytic Streptomyces sp. YIM65484 was selected by biological assay. Four bioactive metabolites were isolated from this strain. Their structures were determined as (2E,4E)-5-(3-hydroxyphenyl)- penta-2,4- dienamide (1), ergosterol (2), ergosterol peroxide (3) and halolitoralin B (4) by spectral analysis. Compound 1 is a new phenylpentadienamide with its rarely encountered skeleton in natural products. Compounds 1-4 showed selectivity for anti-M. Tuberculosis activity in comparison with other antimicrobial activity. Compound 4 was first isolated from Streptomyces.

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@article{2015, title={Anti-Mycobacterium tuberculosis Active Metabolites from an Endophytic Streptomyces sp. YIM65484}, volume={9}, number={196–200}, publisher={Records of Natural Products}, author={Hao Zhou, Lixing Zhao, Wei Li, Yabin Yang, Lihua Xu  Zhongtao Ding}, year={2015} }
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Hao Zhou, Lixing Zhao, Wei Li, Yabin Yang, Lihua Xu  Zhongtao Ding. (2015). Anti-Mycobacterium tuberculosis Active Metabolites from an Endophytic Streptomyces sp. YIM65484 (Vol. 9). Vol. 9. Records of Natural Products.
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Hao Zhou, Lixing Zhao, Wei Li, Yabin Yang, Lihua Xu  Zhongtao Ding. Anti-Mycobacterium Tuberculosis Active Metabolites from an Endophytic Streptomyces Sp. YIM65484. no. 196–200, Records of Natural Products, 2015.
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