Records of Natural Products

Records of Natural Products

Synthesis and Antibacterial Evaluation of Novel Hydrophilic Ocotillol-Type Triterpenoid Derivatives from 20(S)- Protopanaxadiol

Yazarlar: Yi Bi, Cong Ma, Zhiwen Zhou, Tingting Zhang, Hengyuan Zhang, Xiaochen Zhang, Jing Lu, Qingguo Meng, Peter J. Lewis, Jinyi Xu

Cilt 9 , Sayı 3 , 2015 , Sayfalar 356 - 368

Konular:-

Anahtar Kelimeler:Ocotillol,Triterpenoid,Antibacterial activity,Synergistic effect

Özet: Triterpenoid saponins are involved in plant defense systems to inhibit bacterial invasion. A new series of hydrophilic ocotillol-type triterpenoid derivatives 5-26 have been synthesi z ed with antibacterial activity against Gram-positive bacteria, including a community associated methicillin-resistant Staphylococcus aureus (CA-MRSA; strain USA300). From this series, compounds 6 and 15 were found to be the most active, both with MIC values of 2 μg/mL against B. subtilis 168 and 8 μg/mL against S. aureus USA300, respectively. Furthermore, subsequent assays showed that compounds 6 and 15 displayed strong synergistic effects at sub-MIC levels against both S. aureus USA300 and B. subtilis 168 when combined with two commercial antibiotics, kanamycin and chloramphenicol. Preliminary structure-activity relationship studies were also performed.

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@article{2015, title={Synthesis and Antibacterial Evaluation of Novel Hydrophilic Ocotillol-Type Triterpenoid Derivatives from 20(S)- Protopanaxadiol}, volume={9}, number={356–368}, publisher={Records of Natural Products}, author={Yi Bi,, Cong Ma, Zhiwen Zhou, Tingting Zhang, Hengyuan Zhang, Xiaochen Zhang, Jing Lu, Qingguo Meng, Peter J. Lewis,  Jinyi Xu}, year={2015} }
APA
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Yi Bi,, Cong Ma, Zhiwen Zhou, Tingting Zhang, Hengyuan Zhang, Xiaochen Zhang, Jing Lu, Qingguo Meng, Peter J. Lewis,  Jinyi Xu. (2015). Synthesis and Antibacterial Evaluation of Novel Hydrophilic Ocotillol-Type Triterpenoid Derivatives from 20(S)- Protopanaxadiol (Vol. 9). Vol. 9. Records of Natural Products.
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Yi Bi,, Cong Ma, Zhiwen Zhou, Tingting Zhang, Hengyuan Zhang, Xiaochen Zhang, Jing Lu, Qingguo Meng, Peter J. Lewis,  Jinyi Xu. Synthesis and Antibacterial Evaluation of Novel Hydrophilic Ocotillol-Type Triterpenoid Derivatives from 20(S)- Protopanaxadiol. no. 356–368, Records of Natural Products, 2015.
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