Records of Natural Products

Records of Natural Products

Neuroprotective and Antioxidant Constituents from Curcuma zedoaria Rhizomes

Yazarlar: Omer Abdalla Ahmed Hamdi, Lo Jia Ye, Muhamad Noor Alfarizal Kamarudin, Hazrina Hazni, Mohammadjavad Paydar, Chung Yeng Looi, Jamil A. Shilpi, Habsah Abdul Kadir Khalijah Awang

Cilt 9 , Sayı 3 , 2015 , Sayfalar 349 - 355

Konular:-

Anahtar Kelimeler:Curcumenol,Dehydrocurdion,Zerumbone epoxide,ORAC assay,NG108-15 cells

Özet: This study investigates the effect of phytochemical constituents from medicinally important plant Curcuma zedoaria (Christm.) Rosc., on hydrogen peroxide induced oxidative stress in mouse neuroblastoma-rat glioma hybridoma cells NG108-15. Phytochemical investigation of C. zedoaria rhizomes resulted in the isolation of nine sesquiterpenes (germacrone 1, dehydrocurdione 2, curcumenol 3, isoprocurcumenol 5, curcumenone 6, procurcumenol 7, zerumbone epoxide 8, zederone 9 and gweicurculactone 10) and one labdane diterpene (zerumin A 4). Curcumenol (3) and dehydrocurdione (2) showed 100% protection of the NG108-15 cells at the concentrations of 4 and 10 µM, respectively. Procurcumenol (7), isoprocurcumenol (5), zerumbone epoxide (8), zerumin A (4) and germacrone (1) showed moderate activity (80-90% protection). In the oxygen radical antioxidant capacity (ORAC) assay, all the test compounds showed strong antioxidant activity except curcumenol (3) which showed moderate antioxidant activity, as compared to the reference standard quercetin.

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@article{2015, title={Neuroprotective and Antioxidant Constituents from Curcuma zedoaria Rhizomes}, volume={9}, number={349–355}, publisher={Records of Natural Products}, author={Omer Abdalla Ahmed Hamdi, Lo Jia Ye, Muhamad Noor Alfarizal Kamarudin, Hazrina Hazni, Mohammadjavad Paydar, Chung Yeng Looi, Jamil A. Shilpi, Habsah Abdul Kadir  Khalijah Awang}, year={2015} }
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Omer Abdalla Ahmed Hamdi, Lo Jia Ye, Muhamad Noor Alfarizal Kamarudin, Hazrina Hazni, Mohammadjavad Paydar, Chung Yeng Looi, Jamil A. Shilpi, Habsah Abdul Kadir  Khalijah Awang. (2015). Neuroprotective and Antioxidant Constituents from Curcuma zedoaria Rhizomes (Vol. 9). Vol. 9. Records of Natural Products.
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Omer Abdalla Ahmed Hamdi, Lo Jia Ye, Muhamad Noor Alfarizal Kamarudin, Hazrina Hazni, Mohammadjavad Paydar, Chung Yeng Looi, Jamil A. Shilpi, Habsah Abdul Kadir  Khalijah Awang. Neuroprotective and Antioxidant Constituents from Curcuma Zedoaria Rhizomes. no. 349–355, Records of Natural Products, 2015.
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