Records of Natural Products

Yazarlar: Sara Boussaha, Khadidja Bekhouche, Azzedine Boudjerda, Francisco Leόn, Serkan Koldaş, Ayse Sahin Yaglioglu, İbrahim Demirtaş, Ignacio Brouard, Eric Marchioni, Djamila Zama, Samir Benayache Fadila Benayache

Konular:-

Anahtar Kelimeler:Asteraceae,Perralderia coronopifolia,Flavonoids,Caffeoylquinic acids,Terpenoids,Antioxidant activity

Özet: Phytochemical investigations of extracts from the aerial parts (leaves and flowers) of Perralderia coronopifolia Cosson resulted in the isolation of nine secondary metabolites corresponding to three flavonoids: rhamnazin(1), chrysosplenol D (3), and (2R, 3R) taxifolin (4), two monoterpene glycosides : myrtenol- β-D-glucopyranoside- 6'-O-acetate (2) and myrtenol β-D-glucopyranoside (7), a disaccharide: sucrose (9) and three di-O-caffeoylquinic acid derivatives : methyl 3, 5-di-O-caffeoyl quinate (5 ) and methyl 3,4-di-O-caffeoyl quinate (6 ) as a mixture and 1,5-di-O-caffeoylquinic acid (8). The structures were identified by spectroscopic methods such as 1H and 13C NMR, COSY, HSQC and HMBC experiments, HRESI-MS and comparison with literature data. Myrtenol-β-D-glucopyranoside-6'-O-acetate (2) was isolated in pure and native state for the first time. The other compounds are new for the genus Perralderia Cosson. The ethyl acetate extract showed a high antioxidant effect, especially DPPH radical scavenging activity with IC 50=7.01±0.28µg/mL) compared to ascorbic acid ( IC 50= 5±0.1µg/mL . This extract also showed antiproliferative activity against HeLa (human cervix carcinoma) and C6 (rat brain tumor) cells.

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