Records of Natural Products

Records of Natural Products

Stemona Alkaloids Isolated from Stemona tuberosa Roots and their Inhibitory Activity on Lipopolysaccharide-induced Nitric Oxide Production

Yazarlar: Ki Yong Lee, Eun Ju Jeong, Sang Hyun Sung Young Choong Kim

Cilt 10 , Sayı 1 , 2016 , Sayfalar 109 - 112

Konular:-

Anahtar Kelimeler:Stemona tuberose ,Alkaloids ,Lipopolysaccharide ,BV2 microglia ,Nitric oxide

Özet: A methanol extract of the roots of Stemona tuberosa (Stemonaceae) significantly inhibited lipopolysaccharide-induced nitric oxide production in murine BV2 microglial cells. Eight alkaloids tuberostemonine K (1), neotuberostemonine (2), oxotuberostemonine (3), bisdehydroneotuberostemonine (4), epibisdehydrotuberostemonine J (5), bisdehydrotuberostemonine (6), tuberostemoninol (7), and neostenine (8) were isolated from the methanolic extract using bioactivity-guided fractionation. Among them, compounds 4, 5 and 6 showed significant inhibitory effect on lipopolysaccharide-induced nitric oxide production in BV2 microglia at 100 m M.

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@article{2016, title={Stemona Alkaloids Isolated from Stemona tuberosa Roots and their Inhibitory Activity on Lipopolysaccharide-induced Nitric Oxide Production}, volume={10}, number={109–112}, publisher={Records of Natural Products}, author={Ki Yong Lee, Eun Ju Jeong, Sang Hyun Sung  Young Choong Kim}, year={2016} }
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Ki Yong Lee, Eun Ju Jeong, Sang Hyun Sung  Young Choong Kim. (2016). Stemona Alkaloids Isolated from Stemona tuberosa Roots and their Inhibitory Activity on Lipopolysaccharide-induced Nitric Oxide Production (Vol. 10). Vol. 10. Records of Natural Products.
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Ki Yong Lee, Eun Ju Jeong, Sang Hyun Sung  Young Choong Kim. Stemona Alkaloids Isolated from Stemona Tuberosa Roots and Their Inhibitory Activity on Lipopolysaccharide-Induced Nitric Oxide Production. no. 109–112, Records of Natural Products, 2016.
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