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Records of Natural Products
Yazarlar: Vinicius Viana Pereira, Roqueline Rogues Silva , Lucienir Pains Duarte Jacqueline Aparecida Takahashi
Konular:-
Anahtar Kelimeler:Bignoniaceae,Jacaranda oxyphylla,Acetylcholinesterase inhibition,Antibacterial activity
Özet: This study evaluated chemical composition of Jacaranda oxyphylla, acetylcholinesterase inhibitory and antimicrobial activities of the isolated compounds. Phytochemical investigation of leaves extract yielded three classes of substances: fatty compounds, sterols and triterpenes. Butyl hexadecanoate (1), fatty alcohol (2), 2-(4-hydroxyphenyl)ethyl triacontanoate (3), β -sitosterol (4), sitosterol-3-O- β- D -glucoside (5), 6'-palmitoyl-sitosterol-3-O- β- D -glucoside (6), oleanolic acid (7), ursolic acid (8) and corosolic acid (9) were obtained from n-hexane, CHCl 3 and EtOH extracts of J. oxyphylla. It was found a pronounced acetylcholinesterase inhibitory activity for the fatty compounds 1-3 and sterols 5 and 6, with values between 60 to 77%. Substances 7-9 presented a high antibacterial action against Bacillus cereus and Salmonella typhimurium, with values of growth inhibition in the range of 84 to 90%.